2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131118
    Desmethyl Ketoprofen
    		99.72%
    Desmethyl Ketoprofen has anti-inflammatory activities. Desmethyl Ketoprofen can be used for the study of angiogenesis-related disorders.
    Desmethyl Ketoprofen
  • HY-109583
    4-Oxofenretinide
    4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9.
    4-Oxofenretinide
  • HY-126857A
    5-Hydroxyomeprazole sodium
    5-Hydroxyomeprazole sodium is the major metabolite of Omeprazole (HY-B0113). Measuring 5-Hydroxyomeprazole levels in plasma can determine the extent of Omeprazole metabolism.
    5-Hydroxyomeprazole sodium
  • HY-137851
    S-Pyruvylglutathione
    S-Pyruvylglutathione is a serum metabolite and can be used as a potential marker for sensitivity of gastric cancer to neoadjuvant chemotherapy.
    S-Pyruvylglutathione
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3
    		99.65%
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-B0794
    AZ7550
    AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550
  • HY-101677
    cPrPMEDAP
    		99.62%
    cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin.
    cPrPMEDAP
  • HY-100645
    Trimethoprim 3-oxide
    		≥98.0%
    Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim.
    Trimethoprim 3-oxide
  • HY-137565
    Hydroxy ritonavir
    		99.60%
    Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
    Hydroxy ritonavir
  • HY-141530
    Clopidogrel-β-D-glucuronide
    Clopidogrel-β-D-glucuronide is a metabolite of Clopidogrel (HY-15283). Clopidogrel-β-D-glucuronide directly interacts with CYP2C8 enzyme and strongly inhibits the liver enzyme CYP2C8.
    Clopidogrel-β-D-glucuronide
  • HY-101723
    Modecainide
    		99.36%
    Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.
    Modecainide
  • HY-137963
    Daidzein 4'-β-D-glucuronide
    Daidzein 4'-β-D-glucuronide (Compound M4) is a metabolite of Daidzein (HY-N0019).
    Daidzein 4'-β-D-glucuronide
  • HY-135556
    Norfluoxetine
    		98.71%
    Norfluoxetine is the active metabolite of antidepressant Fluoxetine (HY-B0102). Norfluoxetine is a selective inhibitor for serotonin uptake.
    Norfluoxetine
  • HY-137522A
    Zidovudine O-β-D-glucuronide
    Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine O-β-D-glucuronide
  • HY-130465
    7α-Thiospironolactone
    		99.85%
    7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus.
    7α-Thiospironolactone
  • HY-133675
    Mono(5-carboxy-2-ethylpentyl) phthalate
    Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate
  • HY-W008216S
    HMMNI-d3
    		99.90%
    HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections.
    HMMNI-d<sub>3</sub>
  • HY-136456
    2-NP-AMOZ
    2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ
  • HY-W009934
    2-Phenyl-2-(2-pyridyl)acetonitrile
    		99.97%
    2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion.
    2-Phenyl-2-(2-pyridyl)acetonitrile
  • HY-13318A
    Oseltamivir acid hydrochloride
    		≥98.0%
    Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis.
    Oseltamivir acid hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity