2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-117229
    Sonidegib metabolite M48
    		≥98.0%
    Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib.
    Sonidegib metabolite M48
  • HY-117580
    16α-Hydroxyprednisolone
    		99.73%
    16α-Hydroxyprednisolone (OH-PRED) is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid Budesonide (HY-13580). 16α-Hydroxyprednisolone formation is catalyzed by isoenzymes within the cytochrome P450 3A (CYP3A) subfamily. 16α-Hydroxyprednisolone formation can be inhibited by antibodies targeting the CYP3A subfamily.
    16α-Hydroxyprednisolone
  • HY-N10508
    Calcitroic acid
    Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity.
    Calcitroic acid
  • HY-W015788
    1-Phenylethane-1,2-diol
    		99.74%
    1-Phenylethane-1,2-diol (Styrene Glycol) is a benzyl diol compound, which is the major metabolite of Styrene. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics.
    1-Phenylethane-1,2-diol
  • HY-N15358
    15:0-18:1 DG
    		≥99.0%
    15:0-18:1 DG is a type of diacylglycerol (DAG). 15:0-18:1 DG can be produced by hydrolysis of triacylglycerol (TAG) in butter fat. 15:0-18:1 DG is promising for research of obesity, cardiovascular diseases, and dietary interventions.
    15:0-18:1 DG
  • HY-156645
    Tegomil fumarate
    		99.72%
    Tegomil fumarate is a derivative of Monomethyl fumarate (HY-103252) and an immunomodulator. Tegomil fumarate can be used for the study of relapsing remitting multiple sclerosis.
    Tegomil fumarate
  • HY-W013186
    Lansoprazole sulfide
    		99.91%
    Lansoprazole sulfide is an active metabolite of Lansoprazole by cytochrome P450, possesses anti-cancer activity. Lansoprazole sulfide is an anti-tuberculous agent, with an IC50 of 0.59 µM for M. tb.
    Lansoprazole sulfide
  • HY-100646AS
    (Z)-10-Hydroxynortriptyline-d3
    		≥99.0%
    (Z)-10-Hydroxynortriptyline-d3 is the deuterium labeled (Z)-10-Hydroxynortriptyline (HY-100646A). (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (Z)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-114876
    Desmethylflunitrazepam
    Desmethylflunitrazepam (Norflunitrazepam) is a compound from the benzodiazepine family and is an active metabolite of Flunitrazepam.
    Desmethylflunitrazepam
  • HY-W015332
    Captopril EP Impurity D
    Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity D
  • HY-100046S1
    Nordoxepin-d4 hydrochloride
    		99.90%
    Nordoxepin-d4 (Desmethyldoxepin-d4) hydrochloride is deuterium-labeled Nordoxepin (hydrochloride) (HY-100046).
    Nordoxepin-d<sub>4</sub> hydrochloride
  • HY-155792
    Troglitazone glucuronide
    Troglitazone glucuronide (Compound M2) is an initial metabolite of troglitazone in the liver.
    Troglitazone glucuronide
  • HY-G0014
    Quetiapine sulfoxide
    Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine sulfoxide
  • HY-164746
    4′-Hydroxy Nitazene
    		99.6%
    4′-Hydroxy Nitazene is the universal metabolite of the nitazene analogs. 4′-Hydroxy Nitazene is a metabolite of isotonitazene.
    4′-Hydroxy Nitazene
  • HY-W009512
    CVT-2738
    		99.81%
    CVT-2738 is a Ranolazine (HY-B0280) Metabolite, and shows anti-myocardial ischemia activities.
    CVT-2738
  • HY-W778340
    16α-Hydroxy-11-keto prednisolone
    16α-Hydroxy-11-keto prednisolone (compound M-X) is a metabolite of Budesonide (HY-13580). Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist. Budesonide is a widely used for study of asthma, rhinitis, and inflammatory bowel disease.
    16α-Hydroxy-11-keto prednisolone
  • HY-131314
    Ibuprofen carboxylic acid
    Ibuprofen carboxylic acid is the metabolite of Ibuprofen (HY-78131), that has high concentrations in wastewater and water environments, and disappears fast during biodegradation, compared to the other ibuprofen metabolite.
    Ibuprofen carboxylic acid
  • HY-111177R
    Pheneturide (Standard)
    Pheneturide (Standard) is the analytical standard of Pheneturide. This product is intended for research and analytical applications. Pheneturide (Ethylphenacemide, M 551), a decarboxylation product of Phenobarbital, can be used to prevent psychomotor seizures.
    Pheneturide (Standard)
  • HY-W576312
    N,N-Dimethyltryptamine N-oxide
    		99.8%
    N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide
  • HY-W509381
    4-Hydroxyindole-3-acetic acid
    4-Hydroxyindole-3-acetic acid (4HIAA) is a metabolite of Psilocybin and Psilocin.
    4-Hydroxyindole-3-acetic acid
Cat. No. Product Name / Synonyms Application Reactivity