2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-109054
    O-Demethyltramadol
    O-Demethyltramadol is a primary active metabolite of Tramadol. O-Demethyltramadol is mainly responsible for its µ-opioid receptor-related analgesic effect. Tramadol is metabolized to O-Demethyltramadol mainly by the cytochrome P450 (CYP) 2D6 enzyme.
    O-Demethyltramadol
  • HY-156752
    Cyclosiversioside F 16,25-diacetate
    		99.68%
    Cyclosiversioside F 16,25-diacetate (Compound 6), a glycoside, is an alkaline hydrolysis product of Acetyl Derivative (Compound 2).
    Cyclosiversioside F 16,25-diacetate
  • HY-116016
    Etilevodopa
    		99.00%
    Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.
    Etilevodopa
  • HY-124030
    3-Hydroxyphenazepam
    		99.90%
    3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake.
    3-Hydroxyphenazepam
  • HY-12770
    Mebeverine alcohol
    		99.61%
    Mebeverine alcohol is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
    Mebeverine alcohol
  • HY-136560
    6-Azathymine acid
    6-Azathymine acid is a metabolite of Pymetrozine. Pymetrozine is active against plant-sucking insects, such as aphids and whiteflies in vegetables, cotton, field crops and fruits and affects the nervous regulation of feeding behavior.
    6-Azathymine acid
  • HY-132417S
    (rac)-N,O-Didesmethyl Tramadol-d3
    (rac)-N,O-Didesmethyl Tramadol-d3 is a deuterium labeled (rac)-N,O-Didesmethyl Tramadol. (rac)-N,O-Didesmethyl Tramadol is the main metabolite of Tramadol.
    (rac)-N,O-Didesmethyl Tramadol-d<sub>3</sub>
  • HY-136345
    (Rac)-3′-Hydroxy simvastatin
    		99.71%
    (Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    (Rac)-3′-Hydroxy simvastatin
  • HY-Y1117S2
    Melamine-15N3,13C3
    Melamine-15N3,13C3 is a 13C- and 15N-labeled Melamine (HY-Y1117). Melamine is a metabolite of cyromazine. Melamine is a intermediate for the synthesis of melamine resin and plastic materials.
    Melamine-<sup>15</sup>N<sub>3</sub>,<sup>13</sup>C<sub>3</sub>
  • HY-B0794A
    AZ7550 hydrochloride
    		98.66%
    AZ7550 hydrochloride is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550 hydrochloride
  • HY-N10322
    2-Hydroxyemodin
    		99.74%
    2-Hydroxyemodin is an active metabolite of emodin in the hepatic microsomes. Emodin is an anthraquinone present in fungal metabolites and constituent of rhubarb. 2-Hydroxyemodin proves to be mutagenic to Salmonella typhimurium TA1537 in the absence of activation system.
    2-Hydroxyemodin
  • HY-125446
    2-Hydroxymethyl olanzapine
    2-Hydroxymethyl olanzapine is a metabolite and a degradation product of Olanzapine (HY-14541)[1][2].
    2-Hydroxymethyl olanzapine
  • HY-114658
    Daunomycinone
    		98.89%
    Daunomycinone (NSC-109351) is a metabolite of Daunomycin (HY-13062A) and anticancer intermediate. Daunomycinone binds to nucleic acids synergistically with metal ions. Daunomycinone can be used in the research of leukemia.
    Daunomycinone
  • HY-17366R
    Clozapine N-oxide (Standard)
    Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
    Clozapine N-oxide (Standard)
  • HY-148225
    Fulvestrant 3-β-D-Glucuronide
    Fulvestrant 3-β-D-Glucuronide, a metabolite, is glucuronide and sulfate conjugates of Fulvestrant (HY-13636), a pure anti-estrogenic steroid. Fulvestrant 3-β-D-Glucuronide can be used for the research of breast cancer.
    Fulvestrant 3-β-D-Glucuronide
  • HY-136612
    DCBA
    		99.65%
    DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA
  • HY-116617
    15-Keto Travoprost
    		99.20%
    15-Keto Travoprost (15-Keto Fluprostenol isopropyl ester) is a metabolite of Travoprost (HY-B0584). 15-Keto Travoprost shows stimulatory effect on the growth and thickening of the eyelashes.
    15-Keto Travoprost
  • HY-78841
    (2S,4S)-Sacubitril
    (2S,4S)-Sacubitril is the impurity of Sacubitril. Sacubitril is a potent NEP inhibitor that can be used for the research of heart failure.
    (2S,4S)-Sacubitril
  • HY-125780
    5-Phenylhydantoin
    5-Phenylhydantoin is an antiepileptic compound, and has certain hypolipidemic compound.
    5-Phenylhydantoin
  • HY-18719ES
    Endoxifen-d5
    Endoxifen-d5 is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study.
    Endoxifen-d<sub>5</sub>
Cat. No. Product Name / Synonyms Application Reactivity